Wednesday, February 26, 2020 | 4 PM @ 116 Gore Hall

Process Systems Engineering in the Era of Big-Data and Industry 4.0 Revolution


Recent developments towards Industry 4.0 have led to focus in cyber-physical system, internet of things, and smart manufacturing that combined with the huge volume of data generated for the entire manufacturing cycle could lead to complete transformation of manufacturing of products. After the implementation of Industry 4.0 framework, both process and analytical data of the production line can be centralized into a cloud-based platform, where users can retrieve and visualize all relevant manufacturing information in the system. Process Systems Engineering can play a critical role in this revolution with the development of new modeling frameworks and algorithmic solution approaches addressing the issues that classical process systems engineering
tools cannot handle mainly due to computational intractability of multiscale systems, and new design and operations rules that characterize the new systems such as self regulatory structures.
In this talk, our work towards developing process systems engineering tools (models and optimization frameworks) to achieve this goal will be presented and supported by different applications. Pharmaceutical manufacturing of small and large molecules and production of chemicals using renewable sources are among the case studies that are considered.


Marianthi Ierapetritou is the Bob and Jane Gore Centennial Professor in the Department of Chemical and Biomolecular Engineering at University of Delaware. Prior to that she has been a Distinguished Professor in the Department of Chemical and Biochemical Engineering at Rutgers University. During the last year at Rutgers University she led the efforts of the university advancing the careers in STEM for women at Rutgers as an Associate Vice President of the University. Dr. Ierapetritou’s research focuses on the following areas: 1) process operations; (2) design and synthesis of flexible production systems focusing on pharmaceutical manufacturing; 3) energy and sustainability process modeling and operations; and 4) modeling of biopharmaceutical
production. Her research is supported by several federal (FDA, NIH, NSF, ONR, NASA) and industrial (BMS, J&J, GSK, PSE, Bosch, Eli Lilly) grants. Among her accomplishments are appointment as
the Gore Centennial Professor in 2019, the promotion to distinguished professor at Rutgers University in 2017, the 2016 Computing and Systems Technology (CAST) division Award in Computing in Chemical Engineering, the highest distinction in the Systems area of the American Institute of Chemical Engineers (AIChE), the Award of Division of Particulate Preparations and Design (PPD) of The Society of Powder Technology, Japan; the Outstanding Faculty Award at Rutgers; the Rutgers Board of Trustees Research Award for Scholarly Excellence; and the prestigious NSF CAREER award.
She has also been appointed as a Consultant to the FDA under the Advisory Committee for Pharmaceutical Science and Clinical Pharmacology, elected as a fellow of AICHE and as a Director in the board of AIChE. She has more than 250 publications, and has been an invited speaker to numerous national and international conferences. Dr. Ierapetritou obtained her BS from The National Technical University in Athens, Greece, her PhD from Imperial College (London, UK) in 1995 and subsequently completed her post-doctoral research at Princeton University (Princeton, NJ).