April M. Kloxin

Professor

Associate Department Chair

Joint Professor in Materials Science & Engineering

Education 

• Doctorate – 2009 University of Colorado at Boulder
• Masters – 2004 North Carolina State University
• Bachelors – 2001 North Carolina State University

About NAME (h3)

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Select Publications 

For a complete listing of publications, please view the Full CV.

1. EM Ovadia, L Pradhan, LA Sawicki, JE Cowart, RE Huber, SW Polson, C Chen, KL van Golen, KE Ross, CH Wu, AM Kloxin, “Understanding ER+ Breast Cancer Dormancy using Bioinspired Synthetic Matrices for Long-term 3D Culture and Insights into Late Recurrence,” Advanced Biosystems, 4, 9, 2000119, 2020. DOI: 10.1002/adbi.202000119
2. PJ LeValley, R Neelarapu, BP Sutherland, S Dasgupta, CJ Kloxin, AM Kloxin, “Photolabile Linkers: Exploiting labile bond chemistry to control mode and rate of hydrogel degradation and protein release,” Journal of the American Chemical Society, 142, 10, 4671-4679, 2020. DOI: 10.1021/jacs.9b11564
3. AM Hilderbrand, EM Ford, C Guo, JD Sloppy, AM Kloxin, “Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture,” Biomaterials Science, 8, 1256-1269, 2020. DOI: 10.1039/C9BM01894H
4. KL Wiley, EM Ovadia, CJ Calo, RE Huber, AM Kloxin, “Rate-based approach for controlling the mechanical properties of ‘thiol-ene’ hydrogels formed with visible light,” Polymer Chemistry, 10, 4428-4440, 2019. DOI: 10.1039/C9PY00447E
5. LA Sawicki, EM Ovadia, L Pradhan, JE Cowart, KE Ross, CH Wu, AM Kloxin, “Tunable synthetic extracellular matrices to investigate breast cancer response to biophysical and biochemical cues,” APL Bioengineering, 3, 016101, 2019. DOI: 10.1063/1.5064596
6. ME Smithmyer, JB Spohn, AM Kloxin, “Probing fibroblast activation in response to extracellular matrix cues with well-defined culture platform,” ACS Biomaterials Science & Engineering, 4, 3304-3316, 2018. DOI: 10.1021/acsbiomaterials.8b00491
7. LA Sawicki, LH Choe, KL Wiley, KH Lee, AM Kloxin, “Isolation and identification of proteins secreted by cells cultured within synthetic hydrogel-based matrices,” ACS Biomaterials Science and Engineering, 4, 836-845, 2018. DOI: 10.1021/acsbiomaterials.7b00647
8. PM Kharkar, RA Scott, LP Olney, PF Levalley, E Maverakis, KL Kiick, AM Kloxin, “Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential,” Advanced Healthcare Materials, 6, 1700713, 2017. DOI: 10.1002/adhm.201700713
9. C Guo, H Kim, EM Ovadia, CM Mourafetis, M Yang, W Chen, AM Kloxin, “Bio-orthogonal conjugation and enzymatically triggered release of proteins within multi-layered hydrogels,” Acta Biomaterialia, 56, 80-90, 2017. DOI: 10.1016/j.actbio.2017.04.002
10. AM Kloxin, AM Kasko, CN Salinas, and KS Anseth, “Photolabile hydrogels for dynamic tuning of physical and chemical properties,” Science, 324, 59-63, 2009. DOI: 10.1126/science.1169494

Patents (h3)

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Awards 

For a complete listing of awards, please view the Full CV.

1. American Institute of Chemical Engineers (AIChE) Division 15D/E Plenary: 2020
2. NIH Director’s New Innovator Award: 2019
3. Biomaterials Science Lectureship: 2019
4. American Chemical Society PMSE Arthur K. Doolittle Award: 2018
5. American Chemical Society PMSE Young Investigator Honoree: 2017
6. Komen Career Catalyst Research Award: 2016
7. Pew Scholar in Biomedical Sciences: 2013
8. National Science Foundation CAREER Award: 2013

Research Areas

Biomaterials, stimuli-responsive materials, three-dimensional cell culture, tissue engineering, and drug delivery.