Faculty Profile

James N. Michaels

Professor of Practice

Education 

  • Doctorate – 1983 MIT
  • Masters – 1977 University of California, Berkeley
  • Bachelors – 1976 University of California, Berkeley

About James N. Michaels

Professor Jim Michaels is an experienced pharmaceutical executive with an extensive record of achievement in pharmaceutical development, commercialization, and manufacturing support. He worked at Merck & Co. for twenty one years, retiring in 2014 as Associate Vice President. At Merck, he established and directed an industry leading center of excellence in materials science and particle technology. This department supported all product sectors, including small molecules, vaccines and biologics, sterile products, consumer care, and animal health. Jim has globally recognized expertise in materials characterization, particle design, and powder processing and an established track record in solving complex development and manufacturing problems. He is currently serving as Professor of Practice in the Department of Chemical and Biomolecular Engineering at the University of Delaware, developing, administering and teaching a newly-chartered Masters of Engineering in Particle Technology. He is also serving as Vice President of the International Fine Particle Research Institute, responsible for administering IFPRI’s global research program.

Select Publications 

For a complete listing of publications, please view the Full CV.

  1. Gentzler, M., Michaels, J.N., Tardos, G.I., “Quantification of Segregation Potential for Polydisperse, Cohesive, Multi-Component Powders and Prediction of Table Die-Filling Performance — A Methodology for Practical Testing, Re-Formulation and Process Design”, Powder Technology 285, 96, (2015)
  2. J. Michaels, L. Farber, G.S. Wong, K. Hapgood, S.J. Heidel, J. Farabaugh, J-H Chou, G.I. Tardos, “Steady States in Granulation of Pharmaceutical Powders with Application to Scale-Up”, Powder Technology 189, 295, (2009)
  3. J. Michaels, K.P. Hapgood, L. Farber, “Agglomeration of Hydrophobic Powders via Solid Spreading Nucleation”, Powder Technology 188, 248, (2009)
  4. J. Michaels, L. Farber, K.P. Hapgood, X-Y Fu, R. Meyer, M-A Johnson, F. Li, “Unified Compaction Curve Model for Tensile Strength of Tablets Made by Roller Compaction and Direct Compression, International Journal of Pharmaceutics”, International Journal of Pharmaceutics 345 (1-2), 17, (2008)
  5. Tardos, G.I., Hapgood, K.P., Ipadeola, O.O., Michaels, J.N., “Stress Measurements in High-Shear Granulators Using Calibrated “Test” Particles: Application to Scale-Up”, Powder Technology 140, 217, (2004)
  6. Farber, L., Tardos, G., Michaels, J.N., “Use of X-ray Tomography to Student the Porosity and Morphology of Granules”, Powder Technology 132(1), 57, (2003)
  7. J. Michaels, L. Farber, G. Tardos, “Evolution and Structure of Drying Material Bridges of Pharmaceutical Excipients: Studies on a Microscope Slide”, Chemical Engineering Science 58, 4515, (2003)
  8. Litster, J., Hapgood, K., Michaels, J., Sims, A., Roberts, M., Kameneni, S., “Scale-up of Mixer Granulators for Effective Liquid Distribution”, Powder Technology 124(3), 272, (2002)
  9. Litster, J., Hapgood, K., Michaels, J., Sims, A., Roberts, M., Kameneni, S., Hsu, T., “Liquid Distribution in Wet Granulation: Dimensionless Spray Flux”, Powder Technology 114(1-3), 32, (2001)
  10. Bika, D.G., Gentzler, M., Michaels, J.N., “Mechanical Properties of Agglomerates”, Powder Technology 117, 98, (2001)

Patents 

  1. Polymorphic Form of Montelukast Sodium (7,560,559 US Patent): J-H Chou, M.B. Gentzler, M.G. Wu, C. Bazin, S-D Clas, C. Dalton, 2009
  2. Polymorphic Form of Montelukast Sodium (WO/2004/091618 A1): J-H. Chou, M.B. Gentzler, M.G. Wu, C. Bazin, S-D. Clas, C. Dalton, 2004
  3. Process for the Catalytic Dehydrogenation of Alkanes to Alkenes with Simultaneous Combustion of Hydrogen (5,563,314 US Patent): P.A. Agaskar, R.K.Grasselli, P.T. Reischman, D.L. Stern, J.G. Tsikoyiannis, 1996
  4. Process for the Catalytic Dehydrogenation of Alkanes to Alkenes with Simultaneous Combustion of Hydrogen (5,530,171 US Patent): P.A. Agaskar, R.K.Grasselli, P.T. Reischman, D.L. Stern, J.G. Tsikoyiannis, 1996
  5. Process for the Catalytic Dehydrogenation of Alkanes to Alkenes with Simultaneous Combustion of Hydrogen (5,527,979 US Patent): P.A. Agaskar, R.K.Grasselli, P.T. Reischman, D.L. Stern, J.G. Tsikoyiannis, 1996
  6. Process for the Catalytic Dehydrogenation of Alkanes to Alkenes with Simultaneous Combustion of Hydrogen (5,430,209 US Patent): P.A. Agaskar, R.K.Grasselli, P.T. Reischman, D.L. Stern, J.G. Tsikoyiannis, 1995
  7. Process for Oxidative Conversion of Methane to Higher Hydrocarbons Using Metal Sulfide Oxidizing Agent (5,191,138 US Patent): S. Han, R.E. Palermo, D.L. Stern, D.E. Walsh, 1993
  8. Electrocatalytic Energy Conversion and Chemicals Production (4,643,806 US Patent): L.L. Hegedus, C.G. Vayenas, 1987
  9. Fuel Cell and Method for Conducting Gas-Phase Oxidation (4,463,065 US Patent): L.L. Hegedus, C.G. Vayenas, 1984

Awards 

For a complete listing of awards, please view the Full CV.

  1. Phi Beta Kappa Academic Honor Society (University of California, Berkeley)
  2. Graduate Fellow of Rotary International
  3. Sigma Xi Research Honor Society (University of California, Berkeley)
  4. Tau Beta Pi Engineering Honor Society (University of California, Berkeley)
  5. Halcon Fellow (Massachusetts Institute of Technology)
  6. Presidential Young Investigator Award (National Science Foundation)

Research Areas

Particle technology with emphasis in granular flow and segregation, size enlargement, and particle characterization.

Office: CLB
Phone: 302-831-0630
michaeja@udel.edu

PeopleAffiliated FacultyJames N. Michaels