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Faculty Profile

Millicent O. Sullivan

Professor and Associate Chair of Chemical & Biomolecular Engineering

Education 

  • Post-Doctorate – 2006 Hope Heart Program at the Benaroya Research Institute
  • Doctorate – 2003 Carnegie Mellon University
  • Bachelors – 1998 Princeton University

About Millicent Sullivan

Millicent Sullivan is the Centennial Professor and Associate Chair in Chemical & Biomolecular Engineering at the University of Delaware, and a Joint Professor in Biomedical Engineering at UD. Sullivan graduated from Princeton University with a B.S.E. degree in Chemical Engineering and a Certificate in Engineering Biology in 1998. Subsequently, she attended Carnegie Mellon University as a Clare Boothe Luce Graduate Fellow, where she earned her Ph.D. degree in Chemical Engineering with Professor Todd Przybycien in 2003. As a Ruth L. Kirchstein NIH postdoctoral fellow, Sullivan worked with Professor E. Helene Sage in the Matrix Biology/Hope Heart Program of the Benaroya Research Institute. In 2006, Sullivan moved to the University of Delaware. Her laboratory develops new biomaterials for drug delivery, gene delivery, and tissue engineering, with specific therapeutic targets including metastatic breast cancer, bone repair, wound healing, and cardiovascular repair. Specific fundamental foci include de novo peptide design, peptide and polymer self-assembly, and subcellular processing mechanisms. Sullivan is a faculty member in the Delaware Biomaterials COBRE, a member of the Penn Center for Targeted Therapeutics and Translational Nanomedicine (CT3N), an Affiliate Member of the Delaware Biotechnology Institute, and an Affiliate Faculty in the Department of Biomedical Engineering at UD. She was selected as an AIMBE fellow in 2017, named as a Georgia Tech Frontiers in Bioengineering Young Investigator in 2013, selected as the Outstanding Junior Faculty in Engineering at UD in 2011, and has received various other awards including the NSF CAREER Award and a Merck Faculty Fellow Award.

Select Publications 

For a complete listing of publications, please view the Full CV.

  1. Kelley, E.G., Albert, J.N.L., Sullivan, M.O.‡, and Epps, III, T.H.‡, “Stimuli-responsive Copolymer Solution and Surface Assemblies for Biomedical Applications,” Chemical Society Reviews, 42: 7057-7071, (2013)
  2. Kelley, E.G.*, Murphy, R.P.*, Seppala, J.E., Smart, T.P., Hann, S.D., Sullivan, M.O.‡, and Epps, III, T.H.‡, “Size Evolution of Highly Amphiphilic Macromolecular Solution Assemblies via a Distinct Bimodal Pathway,” Nature Communications, 5: 3599. doi:10.1038/ncomms4599, (2014)
  3. Ross, N.L., Munsell, E.V., Sabanayagam, C., and Sullivan, M.O., “Histone-Targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Post-mitotic Redistribution of ER Membranes,” Molecular Therapy Nucleic Acids, 4, e226, doi:10.1038/mtna.2015.2, (2015)
  4. Munsell, E.V., Ross, N.L., and Sullivan, M.O., “Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus,” Current Pharmaceutical Design, 22(9): 1227-1244, (2016)
  5. Greco, C.T., Epps III, T.H.‡, and Sullivan, M.O.‡, “Mechanistic Design of Polymer Nanocarriers to Spatiotemporally Control Gene Silencing,” ACS Biomaterials Science and Engineering, doi:10.1021/acsbiomaterials.6b00336, (2016)
  6. Urello, M.A., Kiick, K.L.‡, and Sullivan, M.O.‡, “Integration of Growth Factor Gene Delivery with Collagen-Triggered Wound Repair Cascades using Collagen-Mimetic Peptides,” Bioengineering & Translational Medicine, doi:10.1002/btm2.10037, (2016)
  7. Greco, C.T., Muir, V.M., Epps III, T.H.‡, and Sullivan, M.O.‡, “Efficient Tuning of siRNA Dose Response by Combining Mixed Polymer Nanocarriers with Simple Kinetic Modeling,” Acta Biomaterialia, doi:10.1016/j.actbio.2017.01.003, (2017)
  8. Urello, M.A., Kiick, K.L.‡, and Sullivan, M.O.‡, “ECM Turnover-Stimulated Gene Delivery through CMP-Plasmid Integration in Collagen,” Acta Biomaterialia, 62: 167-178, (2017)
  9. Munsell, E.V., Kurpad, D., Freeman, T., and Sullivan, M.O., “Histone-Targeted Gene Transfer of Bone Morphogenetic Protein-2 Enhances Mesenchymal Stem Cell Chondrogenic Differentiation,” Acta Biomaterialia, 71: 156-157, (2018)
  10. Lieser, R.M., Chen, W., and Sullivan, M.O., “Controlled EGFR Ligand Display on Cancer Suicide Enzymes via UAA Engineering for Enhanced Intracellular Delivery in Breast Cancer Cells,” Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.8b00783, (2019)

Patents (h3)

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Awards 

For a complete listing of awards, please view the Full CV.

  1. Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2017
  2. Georgia Tech Frontiers in Bioengineering Young Investigator, 2013
  3. Outstanding Junior Faculty Member in the College of Engineering, 2011
  4. Merck Faculty Fellow, 2008
  5. National Science Foundation (NSF) CAREER Award, 2008

Research Areas 

Drug delivery, gene delivery, biomaterials and stimuli-responsive materials, tissue engineering and regenerative medicine

Office: 213 CLB
Phone: 302-831-8072
msullivan@udel.edu

People Faculty Millicent O. Sullivan